Protein Details: Potassium voltage-gated channel subfamily A member 7
Protein ID
ICDB_Pro_0853
Protein Name
Potassium voltage-gated channel subfamily A member 7
Gene Name
Kcna7; Kcnc7
Organism
Mus musculus (Mouse)
Length
489 amino acids
AlphaFoldDB
AF-Q17ST2-F1-model_v4.pdb
Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2
Sequence
MLFLPADTGHPTGVAAASGPHVRSPVARAVRAMEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPVRRSRFYDGARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVSFYGLGAAALARLREDEGCAVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDDPGLAPVAAATGPFLARLNGSSPMPGAPPRQPFNDPFFVVETLCICWFSFELLVRLVACPSKAVFFKNVMNLIDFVAILPYFVALGTELARQRGVGQPAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDTHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMYSHVDTQPCGTLEGKANGGLVDSEVPELLPPLWPPAGKHMVTEV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Detected in heart; skeletal muscle; brain; and pancreatic islet cells.
DOI ID
10.1074/jbc.273.10.5851; 10.1085/jgp.200609498; 10.1038/sj.ejhg.5200739
RefSeq
NP_034726.2 [Q17ST2-1]